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Trifluoroacetic acid → 2-(Benzamido)-4-(2,4-dichlorophenoxy)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Tert-butyl 2-(benzamido)-4-(2,4-dichlorophenoxy)benzoate | HCID 67342198 | — |
| 生成物 | 2-(Benzamido)-4-(2,4-dichlorophenoxy)benzoic acid | HCID 57879621 | — |
反応手順
5.0 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(benzamido)-4-(2,4-dichlorophenoxy)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and the obtained residue was purified with reversed-phase silica gel column chromatography [eluent; 80-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to obtain 8.7 mg of 2-(benzamido)-4-(2,4-dichlorophenoxy)benzoic acid as white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07999132B2 |
| 出典データセット | uspto-grants-2011_08 |
| ORD ID | ord-05c7ce13af0f4ca8a6a64359620e79af |
| 出典メモ | uspto-grants-2011_08 |