Isoamyl acetoacetate → Isoamyl-alpha-acetyl-3-methoxy-4-hydroxy-5-isopropyl-cinnamate
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([CH:12]([CH3:14])[CH3:13])[C:10]=1[OH:11])[CH:6]=O.[C:15]([O:21][CH2:22][CH2:23][CH:24]([CH3:26])[CH3:25])(=[O:20])[CH2:16][C:17]([CH3:19])=[O:18].N1(CC(O)=O)CCCCC1>C1C=CC=CC=1>[CH2:22]([O:21][C:15](=[O:20])[C:16]([C:17](=[O:18])[CH3:19])=[CH:6][C:5]1[CH:8]=[C:9]([CH:12]([CH3:14])[CH3:13])[C:10]([OH:11])=[C:3]([O:2][CH3:1])[CH:4]=1)[CH2:23][CH:24]([CH3:26])[CH3:25]参加物
5
実験手順
Condensation of 3-methoxy-4-hydroxy-5-isopropyl benzaldehyde with isoamyl acetoacetate in the presence of piperidine-acetic acid and benzene as the reaction medium at reflux temperature under continuous azeotropic water removal yields the title product. The reaction takes about 4 hrs for completion. The yield obtained is typically 90-95%.