2-chloro-N-(2-phenylethyl)propanamide → HCID 57437916、化合物
反応式
Cl[CH:2]([CH3:14])[C:3]([NH:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:4].[Cl-].[Cl-].[Cl-].[Al+3]>O.CO>[CH3:14][CH:2]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH2:7][CH2:6][NH:5][C:3]1=[O:4]参加物
5
反応条件
- 温度
- 150 °C
実験手順
8.0 g (37 mmol) 2-chloro-N-(2-phenylethyl)-propanamide and 15 g (112 mmol) aluminium trichloride are carefully mixed at 90° C. and heated to 150° C. for 6 h. The mixture is diluted with water and methanol and extracted with EtOAc. The combined organic phases are dried with Na2SO4, concentrated i. vac. and purified by chromatography.
後処理
- extractionextracted with EtOAc
- dry with materialThe combined organic phases are dried with Na2SO4
- concentrationconcentrated i
- customand purified by chromatography
出典と根拠
- ORDレコード
- ord-b8e66e1a7fa8451e91c97e6352ae81b8
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US08003639B2
反応ノート
読み込み中…