6-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazine → 4-(6-Chloropyridin-3-yl)-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol

HRID 1675023

反応式

HRID 1675023 の反応式
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2([OH:14])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl[C:16]1[CH:17]=[CH:18][C:19]2[N:20]([C:22]([C:25]([F:28])([F:27])[F:26])=[N:23][N:24]=2)[N:21]=1>>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2([OH:14])[CH2:9][CH2:10][N:11]([C:16]3[CH:17]=[CH:18][C:19]4[N:20]([C:22]([C:25]([F:26])([F:28])[F:27])=[N:23][N:24]=4)[N:21]=3)[CH2:12][CH2:13]2)=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 6136576-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazineHCID 211055334-(6-Chloropyridin-3-yl)piperidin-4-ol

生成物 1

HCID 591496924-(6-Chloropyridin-3-yl)-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol収率 80%

実験手順

A mixture of 4-(6-chloropyridin-3-yl)piperidin-4-ol and 6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by the method of Example 306 to give 4-(6-chloropyridin-3-yl)-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol in 80% yield.

後処理

  1. customto react by the method of Example 306

出典と根拠

ORDレコード
ord-153e0ddda0ea46fd864b242476e90691
出典データセット
uspto-grants-2011_08
特許番号
US08003649B2

関連ノート

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