反応式
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.Cl[C:16]1[CH:17]=[CH:18][C:19]2[N:20]([C:22]([C:25]([Cl:28])([F:27])[F:26])=[N:23][N:24]=2)[N:21]=1>>[Cl:28][C:25]([F:26])([F:27])[C:22]1[N:20]2[N:21]=[C:16]([N:12]3[CH2:11][CH2:10][N:9]([C:3]4[C:2]([CH3:1])=[CH:7][CH:6]=[CH:5][C:4]=4[CH3:8])[CH2:14][CH2:13]3)[CH:17]=[CH:18][C:19]2=[N:24][N:23]=1参加物
3
実験手順
A mixture of 1-(2,6-dimethylphenyl)piperazine and 6-chloro-3-[chloro(difluoro)methyl]-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by an analogous method to Example 339 to give 3-[chloro(difluoro)methyl]-6-[4-(2,6-dimethylphenyl)piperazin-1-yl][1,2,4]triazolo[4,3-b]pyridazine in 64% yield.
後処理
- customto react by an analogous method to Example 339
出典と根拠
- ORDレコード
- ord-f42a11b35be04a92af76c01dfd504664
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US08003649B2
関連ノート
読み込み中…