6-[4-[2-(Difluoromethyl)-5-fluorobenzyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine → 6-[4-[2-(Difluoromethyl)-5-fluorobenzyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine
反応式
[N:1]1([C:7]2[CH:8]=[CH:9][C:10]3[N:11]([C:13]([C:16]([F:19])([F:18])[F:17])=[N:14][N:15]=3)[CH:12]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[F:20][CH:21]([F:49])[C:22]1[CH:47]=[CH:46][C:45]([F:48])=[CH:44][C:23]=1[CH2:24]N1CCN(C2C=CC3N(C(C(F)(F)F)=NN=3)N=2)CC1>>[F:49][CH:21]([F:20])[C:22]1[CH:47]=[CH:46][C:45]([F:48])=[CH:44][C:23]=1[CH2:24][N:4]1[CH2:3][CH2:2][N:1]([C:7]2[CH:8]=[CH:9][C:10]3[N:11]([C:13]([C:16]([F:18])([F:17])[F:19])=[N:14][N:15]=3)[CH:12]=2)[CH2:6][CH2:5]1参加物
3
反応物 2
生成物 1
実験手順
Obtained in 39% yield by General Synthetic Method 9, starting from 6-(piperazin-1-yl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine and 2-difluoromethyl-5-fluorobenzaldehyde (obtained as described in Example 779, preparation of starting materials).