Cesium carbonate → (S)-3-((S)-3-(4-(4-Bromo-3-(trifluoromethoxy)benzyloxy)-phenyl)-3-(isoxazol-3-yl)propanoyl)-4-benzyloxazolidin-2-one

A mixture of 28.3 (1.30 g, 4.80 mmol), thionyl bromide (1.01 g, 4.84 mmol), and DMF (0.1 mL) in DCM (8.0 mL) was stirred at room temperature for 50 minutes. The solvent was then removed. To the residue was added 7.5 (1.10 g, 2.80 mmol) and Cs2CO3 (1.10 g, 3.36 mmol) in DMF (8.0 mL). The mixture was stirred at room temperature for 4 hours. EtOAc (150 mL) was added, and the mixture was washed with brine (25×3 mL) and dried with MgSO4. The solvent was removed, and the crude product was purified by CombiFlash, eluting with EtOAc and hexane, to give the title compound 28.4. 1H NMR (CDCl3) δ 2.77 (dd, J=4.2, 9.5 Hz, 1 H), 3.21 (dd, J=4.2, 9.5 Hz, 1 H), 3.52 (dd, J=8.6, 17.6 Hz, 1 H), 4.04 (dd, J=8.6, 17.6 Hz, 1 H), 4.63 (m, 1 H), 4.76 (m, 1 H), 5.01 (s, 2 H), 6.14 (d, J=1.5 Hz, 1 H), 6.92 (d, J=6.9,Hz, 2 H), 7.20-7.35 (m, 9 H), 7.64 (d, J=8.3,Hz, 1H), 8.31 (d, J=1.5 Hz, 1 H). MS ESI (pos.) m/e: 647 (M+H).

1. customThe solvent was then removed
2. stirringThe mixture was stirred at room temperature for 4 hours
3. washthe mixture was washed with brine (25×3 mL)
4. dry with materialdried with MgSO4
5. customThe solvent was removed
6. customthe crude product was purified by CombiFlash
7. washeluting with EtOAc and hexane

ORDレコード

ord-4ad66d2857774da1a770f3fabec82fbc

出典データセット

uspto-grants-2011_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08003648B2