Phenethylamine → N-Phenethyl-6-[5-(2-trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrole-2-yl]nicotinamide

反応式

[F:1][C:2]([F:29])([F:28])[C:3]1[CH:27]=[CH:26][CH:25]=[CH:24][C:4]=1[C:5]([N:7]1[CH2:11][C:10]2[CH2:12][N:13]([C:15]3[CH:23]=[CH:22][C:18]([C:19](O)=[O:20])=[CH:17][N:16]=3)[CH2:14][C:9]=2[CH2:8]1)=[O:6].[C:30]1([CH2:36][CH2:37][NH2:38])[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[CH2:37]([NH:38][C:19](=[O:20])[C:18]1[CH:22]=[CH:23][C:15]([N:13]2[CH2:12][C:10]3[CH2:11][N:7]([C:5](=[O:6])[C:4]4[CH:24]=[CH:25][CH:26]=[CH:27][C:3]=4[C:2]([F:29])([F:1])[F:28])[CH2:8][C:9]=3[CH2:14]2)=[N:16][CH:17]=1)[CH2:36][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1

参加物

反応物 2

HCID 1001Phenethylamine

HCID 584597846-[5-(2-Trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl]nicotinic acid

生成物 1

HCID 25105829N-Phenethyl-6-[5-(2-trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrole-2-yl]nicotinamide収率 45%

実験手順

6-[5-(2-Trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl]nicotinic acid (50 mg, 0.124 mmol) was reacted with 2-phenylethylamine analogously to example 3d. Yield: 45%, M+H+: 507.28.

出典と根拠

ORDレコード: ord-4ea7b83396f84557a670deac8a405814
出典データセット: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08003677B2

反応ノート

読み込み中…