(S)-tert-butyl-5-(nitrooxy)hexanoate → (S)-5-(nitrooxy)hexanoic acid

HRID 1676010ノート

反応式

HRID 1676010 の反応式
C([O:5][C:6](=[O:16])[CH2:7][CH2:8][CH2:9][C@@H:10]([O:12][N+:13]([O-:15])=[O:14])[CH3:11])(C)(C)C>C(Cl)Cl>[N+:13]([O:12][C@@H:10]([CH3:11])[CH2:9][CH2:8][CH2:7][C:6]([OH:16])=[O:5])([O-:15])=[O:14]

参加物

3

反応物 1

HCID 58231672(S)-tert-butyl-5-(nitrooxy)hexanoate

生成物 1

HCID 58231663(S)-5-(nitrooxy)hexanoic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(S)-tert-butyl-5-(nitrooxy)hexanoate (590 mg, 2.53 mmol), was dissolved in CH2Cl2 (20 mL). HClgas was bubbled into the solution until the disappearance of the starting material. The solution was reduced to a small volume and diluted in CH2Cl2 few times to remove residual acidity, then used without further purification.

後処理

  1. customHClgas was bubbled into the solution until the disappearance of the starting material
  2. additiondiluted in CH2Cl2 few times
  3. customto remove residual acidity
  4. customused without further purification

出典と根拠

ORDレコード
ord-484fde50b49a4e15a7d1d02cdd4e4e35
出典データセット
uspto-grants-2011_08
特許番号
US08003811B2

反応ノート

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