Ethyl 3-phenyl-3-[6-(trifluoromethyl)-1H-benzimidazol-1-yl]propanoate → 3-Phenyl-3-[6-(trifluoromethyl)-1H-benzimidazol-1-yl]propanoic acid

HRID 1676030ノート

反応式

HRID 1676030 の反応式
[C:1]1([CH:7]([N:14]2[C:18]3[CH:19]=[C:20]([C:23]([F:26])([F:25])[F:24])[CH:21]=[CH:22][C:17]=3[N:16]=[CH:15]2)[CH2:8][C:9]([O:11]CC)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>Cl>[C:1]1([CH:7]([N:14]2[C:18]3[CH:19]=[C:20]([C:23]([F:26])([F:25])[F:24])[CH:21]=[CH:22][C:17]=3[N:16]=[CH:15]2)[CH2:8][C:9]([OH:11])=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

3

反応物 1

HCID 67353239Ethyl 3-phenyl-3-[6-(trifluoromethyl)-1H-benzimidazol-1-yl]propanoate

生成物 1

HCID 115808103-Phenyl-3-[6-(trifluoromethyl)-1H-benzimidazol-1-yl]propanoic acid

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A solution of ethyl 3-phenyl-3-[6-(trifluoromethyl)-1H-benzimidazol-1-yl]propanoate (74 mg, 204 μmol) in hydrochloric acid (10 mL of a 5N solution) was stirred at room temperature for 96 hours. The solution was evaporated in vacuo to afford the title compound, [LCMS (Method A, Mobile Phase II) RT=4.07 min, MH+ 335].

後処理

  1. customThe solution was evaporated in vacuo

出典と根拠

ORDレコード
ord-cd220a921c64492fb0b51e5c10916dd1
出典データセット
uspto-grants-2011_08
特許番号
US08003806B2

反応ノート

読み込み中…