2-Chlorophenyl chloroformate → HCID 25204383、化合物

HRID 1676164

反応式

HRID 1676164 の反応式
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH:16]=[CH:15][C:14]([O:17][CH:18]3[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]3)=[CH:13][C:12]2=[O:31])=[CH:7][CH:6]=1)(=[O:4])=[O:3].Cl[C:33]([O:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=1[Cl:42])=[O:34].ClC(OC(C)C(F)(F)F)=O>>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([N:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH:19]3[CH2:23][CH2:22][N:21]([C:33]([O:35][C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=4[Cl:42])=[O:34])[CH2:20]3)=[CH:13][C:12]2=[O:31])=[CH:9][CH:10]=1)(=[O:4])=[O:3]

参加物

4

反応物 3

HCID 41840682-Chlorophenyl chloroformateHCID 25204174Tert-butyl 4-(1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylateHCID 582703481,1,1-Trifluoropropan-2-yl carbonochloridate

生成物 1

HCID 25204383HCID 25204383、化合物

実験手順

Example 19 was prepared according to procedures described in Example 2, Step A and Step C, substituting tert-butyl 3-((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)methyl)pyrrolidine-1-carboxylate for tert-butyl 4-(1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate in Step A and 2-chlorophenyl chloroformate for 1,1,1-trifluoropropan-2-yl chloroformate in Step C. 1H NMR (500 MHz, CDCl3) δ 8.08 (d, J=8.80 Hz, 2H), 7.61 (d, J=8.80 Hz, 2H), 7.43 (d, J=8.25 Hz, 1H), 7.23-7.31 (m, 3H), 7.14-7.19 (m, 1H), 6.10-6.21 (m, 2H), 3.38-4.14 (m, 6H), 3.10 (s, 3H), 2.77-2.93 (m, 1 H), 2.15-2.32 (m, 1H), 1.83-2.00 (m, 1H). MS (ESI) 503 (M+H).

後処理

  1. customExample 19 was prepared

出典と根拠

ORDレコード
ord-3f2c9faac2a7435991977f6ab7d3e410
出典データセット
uspto-grants-2011_08
特許番号
US08003796B2

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