Hydrochloric Acid → 1-(2,2-Difluoroethyl)piperidin-4-amine Dihydrochloride
反応式
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH:15]([F:17])[F:16])[CH2:10][CH2:9]1)(C)(C)C.[ClH:19]>O1CCOCC1>[ClH:19].[ClH:19].[F:17][CH:15]([F:16])[CH2:14][N:11]1[CH2:10][CH2:9][CH:8]([NH2:7])[CH2:13][CH2:12]1参加物
4
実験手順
To a cooled (0 degrees) mixture of 1.21 g (4.58 mmole) of [1-(2,2-difluoro-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester and 20 mL of dioxane, was added 5.7 mL of 4M HCl in dioxane. The mixture was stirred at room temperature overnight, and the solid collected by filtration to give 0.90 g of 1-(2,2-difluoro-ethyl)-piperidin-4-ylamine dihydrochloride.
後処理
- temperatureTo a cooled
- filtrationthe solid collected by filtration
出典と根拠
- ORDレコード
- ord-e09a25ffa64343cc9ed69e9edec03e59
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US08003785B2
反応ノート
読み込み中…