Hydrochloric Acid → 1-(3-Methanesulfonyl-propyl)-piperidin-4-ylamine dihydrochloride

HRID 1676526ノート

反応式

HRID 1676526 の反応式
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][S:17]([CH3:20])(=[O:19])=[O:18])[CH2:10][CH2:9]1)(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[ClH:22].[CH3:20][S:17]([CH2:16][CH2:15][CH2:14][N:11]1[CH2:12][CH2:13][CH:8]([NH2:7])[CH2:9][CH2:10]1)(=[O:19])=[O:18]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 67355480[1-(3-Methanesulfonyl-propyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

生成物 1

HCID 673553041-(3-Methanesulfonyl-propyl)-piperidin-4-ylamine dihydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

To a cooled (0 degrees) mixture of 3.6 g (0.0113 mole) of [1-(3-methanesulfonyl-propyl)-piperidin-4-yl]-carbamic acid tert-butyl ester and 30 mL of dioxane, was added 14.1 mL of 4M HCl in dioxane. The mixture was stirred 18 hours at room temperature, and the solid collected by filtration to give 2.3 g of 1-(3-methanesulfonyl-propyl)-piperidin-4-ylamine dihydrochloride.

後処理

  1. temperatureTo a cooled
  2. filtrationthe solid collected by filtration

出典と根拠

ORDレコード
ord-7c4232b425dd4a1f8999d9e3ac9d02d4
出典データセット
uspto-grants-2011_08
特許番号
US08003785B2

反応ノート

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