Hydrochloric Acid → HCID 21952711、化合物
反応式
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9]N.[NH:11]1[CH2:16][CH2:15][C:14](=O)[CH2:13][CH2:12]1.Cl>C(O)C>[CH3:1][S:2][C:3]1[C:4]2[NH:9][C:14]3[CH2:15][CH2:16][NH:11][CH2:12][C:13]=3[C:5]=2[CH:6]=[CH:7][CH:8]=1参加物
5
実験手順
The 2-(methylthio)phenyl hydrazine (5.32 g, 30.0 mmol) and 4-piperidone (4.07 g, 30.0 mmol) were partially dissolved in the ethanol (75 mL) and heated initially to reflux for 1 h. A heavy precipitate formed from the almost clear solution. The reaction was then treated with the conc hydrochloric acid (2.5 mL) and diluted with further ethanol (25 mL) to assist stirring and heating continued for a further 4 h. After cooling to RT overnight the solid was filtered washing isopropanol (25 mL). Obtained 7.70 g
後処理
- temperatureheated initially
- temperatureto reflux for 1 h
- customA heavy precipitate formed from the almost clear solution
- temperatureheating
- filtrationwas filtered
- washwashing isopropanol (25 mL)
- customObtained 7.70 g
出典と根拠
- ORDレコード
- ord-f238cd7d368b44e6905c72afd2188f9b
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US08008279B2
反応ノート
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