Tert-Butylamine → HCID 59540884、化合物

反応式

[CH3:1][C:2]1[N:22]([CH2:23][O:24][CH2:25][CH2:26][Si:27]([CH3:30])([CH3:29])[CH3:28])[C:5]2=[N:6][CH:7]=[C:8]([C:10]3[CH:15]=[C:14]([O:16][CH3:17])[C:13]([O:18][CH3:19])=[C:12]([O:20][CH3:21])[CH:11]=3)[N:9]=[C:4]2[C:3]=1[C:31]([OH:33])=O.C1CN([P+](ON2N=NC3C=CC=CC2=3)(N2CCCC2)N2CCCC2)CC1.F[P-](F)(F)(F)(F)F.[C:67]([NH2:71])([CH3:70])([CH3:69])[CH3:68]>CN(C=O)C>[C:67]([NH:71][C:31]([C:3]1[C:4]2[C:5](=[N:6][CH:7]=[C:8]([C:10]3[CH:15]=[C:14]([O:16][CH3:17])[C:13]([O:18][CH3:19])=[C:12]([O:20][CH3:21])[CH:11]=3)[N:9]=2)[N:22]([CH2:23][O:24][CH2:25][CH2:26][Si:27]([CH3:28])([CH3:30])[CH3:29])[C:2]=1[CH3:1])=[O:33])([CH3:70])([CH3:69])[CH3:68]

参加物

実験手順

To a solution of 6-Methyl-2-(3,4,5-trimethoxy-phenyl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (95 mg) in 1.5 mL of DMF was added PyBOP (128 mg) followed by tert-Butyl amine (70 mg). After stirring for 2 h, the mixture was partitioned between water and diethylether. The organic phase was washed with brine, dried over Na2SO4, filtered, and concentrated. Flash chromatography (4:1 Hexanes:ethylacetate) afforded 70 mg of 6-Methyl-2-(3,4,5-trimethoxy-phenyl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid tert-butylamide.