Triacetoxyperiodinane → HCID 59540695、化合物
反応式
[F:1][C:2]([F:12])([F:11])[C:3]([CH3:10])([C:6]([F:9])([F:8])[F:7])[CH2:4][OH:5].CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O>>[F:1][C:2]([F:11])([F:12])[C:3]([CH3:10])([C:6]([F:7])([F:9])[F:8])[CH:4]=[O:5]参加物
3
反応条件
- 温度
- 100 °C
実験手順
3,3,3-Trifluoro-2-methyl-2-trifluoromethyl-propan-1-ol, 1 gm, 5.1 mM, and Dess-Martin Periodinane, 4.3 gm, 10.2 mM, 2 eq. was added to ten ml of 1,1,1,3 tetrachloroethane and the mixture stirred for several hours. A short path distillation head was added and the receiver flask was cooled in dry ice-acetone bath. The mixture was heated to 100° C. and the pressure lowered to 180 Ton. The desired product 3,3,3-Trifluoro-2-methyl-2-trifluoromethyl-propionaldehyde condensed in the receiver flask and was used without further purification in the above reaction.
後処理
- distillationA short path distillation head
- additionwas added
- temperaturethe receiver flask was cooled in dry ice-acetone bath
- customThe desired product 3,3,3-Trifluoro-2-methyl-2-trifluoromethyl-propionaldehyde condensed in the receiver flask
- customwas used without further purification in the above reaction
出典と根拠
- ORDレコード
- ord-e704309765e7428b8be03d1f1c6a7df3
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US08008298B2
反応ノート
読み込み中…