3-(Aminosulphonyl)benzeneboronic acid → HCID 59540638、化合物

HRID 1677448

反応式

HRID 1677448 の反応式
Br[C:2]1[N:3]=[C:4]2[C:10]([C:11](=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.[NH2:17][S:18]([C:21]1[CH:22]=[C:23](B(O)O)[CH:24]=[CH:25][CH:26]=1)(=[O:20])=[O:19]>CCOC(C)=O>[CH3:13][C:12]([CH3:15])([CH3:14])[C:11]([C:10]1[C:4]2[C:5](=[N:6][CH:7]=[C:2]([C:25]3[CH:26]=[C:21]([S:18]([NH2:17])(=[O:20])=[O:19])[CH:22]=[CH:23][CH:24]=3)[N:3]=2)[NH:8][CH:9]=1)=[O:16]

参加物

4

反応物 2

HCID 441193233-(Aminosulphonyl)benzeneboronic acidHCID 578292181-(2-Bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

生成物 1

HCID 59540638HCID 59540638、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

3-[7-(2,2-Dimethyl-propionyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-benzenesulfonamide was prepared starting from 1-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethyl-propan-1-one and (3-aminosulfonylphenyl)Boronic Acid following general procedures as described in these Examples. Silica gel chromatography using 20-100% EtOAc in hexanes as eluant provided 60 mg (37%) of a pale yellow solid. MP 275-277° C., M+H=359.

出典と根拠

ORDレコード
ord-f77e56c40f2d4b919929f1bba60e7fe1
出典データセット
uspto-grants-2011_08
特許番号
US08008298B2

関連ノート

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