2-Azabicyclo(2.1.1)hexane hydrochloride → HCID 59540831、化合物

反応式

I[C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[C:10]3[C:16]([C:17](=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19])=[CH:15][N:14]([CH2:23][O:24][CH2:25][CH2:26][Si:27]([CH3:30])([CH3:29])[CH3:28])[C:11]3=[N:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1.Cl.[CH:32]12[CH2:37][CH:35]([CH2:36]1)[CH2:34][NH:33]2>>[CH:32]12[CH2:37][CH:35]([CH2:36]1)[CH2:34][N:33]2[C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[C:10]3[C:16]([C:17](=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19])=[CH:15][N:14]([CH2:23][O:24][CH2:25][CH2:26][Si:27]([CH3:30])([CH3:29])[CH3:28])[C:11]3=[N:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1

参加物

反応物 2

HCID 552197462-Azabicyclo(2.1.1)hexane hydrochloride

HCID 595405201-[2-(3-iodo-phenyl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one

生成物 1

HCID 59540831HCID 59540831、化合物

実験手順

1-[2-[3-(2-Azabicyclo[2.1.1]hex-2-yl)-phenyl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one was prepared from 1-[2-(3-Iodo-phenyl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one and 2-azabicyclo[2.1.1]hexane hydrochloride as described above (34%; MS=361 M+H).

出典と根拠

ORDレコード: ord-479b38d23d144b15859bcc579876b801
出典データセット: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08008298B2

反応ノート

読み込み中…