化工社化工社 化学情報印刷レポート · 研究参考用
Ammonium Chloride → 4-Amino-7-(trifluoromethyl)quinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | 4-Chloro-7-(trifluoromethyl)quinoline | HCID 67668 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-Amino-7-(trifluoromethyl)quinoline | HCID 2735960 | — |
反応手順
A solution of 4-chloro-7-trifluoromethylquinoline (1 g) and ammonium chloride (1 g) in methanol (10 mL) was heated at 70° C. overnight. Then the solid was filtered off and washed with methanol. The filtrated was evaporated to give 4-amino-7-trifluoromethylquinoline. LCMS: ret. time: 14.81 min.; purity: 82.25%; MS (m/e): 228.11 (M+16).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08008501B2 |
| 出典データセット | uspto-grants-2011_08 |
| ORD ID | ord-2299b1780c344cf68e6af34e073ce4f6 |
| 出典メモ | uspto-grants-2011_08 |