Phosphorus pentachloride → 6-Fluoro-2-methylquinoline-4-carbonyl chloride

HRID 1678310ノート

反応式

HRID 1678310 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH3:12])[CH:6]=[C:5]2[C:13]([OH:15])=O.P(Cl)(Cl)(Cl)(Cl)[Cl:17]>ClCCl>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH3:12])[CH:6]=[C:5]2[C:13]([Cl:17])=[O:15]

参加物

4

反応物 2

HCID 24819Phosphorus pentachlorideHCID 6931066-Fluoro-2-methylquinoline-4-carboxylic acid

生成物 1

HCID 860425596-Fluoro-2-methylquinoline-4-carbonyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 6-fluoro-2-methylquinoline-4-carboxylic acid (500 mg) and PCl5 (500 mg) in dichloromethane (10 mL) was refluxed for half an hour. Then dichloromethane and POCl3 were removed under reduced pressure to give 6-fluoro-2-methylquinoline-4-carbonyl chloride.

後処理

  1. customThen dichloromethane and POCl3 were removed under reduced pressure

出典と根拠

ORDレコード
ord-88bcd09445bd4546a180035d1a392a38
出典データセット
uspto-grants-2011_08
特許番号
US08008501B2

反応ノート

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