Triethylamine → [2-Methyl-3'-(4-morpholin-4-yl-phenylcarbamoyl)-biphenyl-4-yl]-carbamic acid tert-butyl ester

HRID 1678458ノート

反応式

HRID 1678458 の反応式
[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21](O)=[O:22])[CH:16]=2)=[C:11]([CH3:24])[CH:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[N:25]1([C:31]2[CH:37]=[CH:36][C:34]([NH2:35])=[CH:33][CH:32]=2)[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1.C(N(CC)CC)C.F[P-](F)(F)(F)(F)F.N1(OC(N(C)C)=[N+](C)C)C2C=CC=CC=2N=N1>CN(C=O)C.O>[C:1]([O:5][C:6](=[O:7])[NH:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21](=[O:22])[NH:35][C:34]3[CH:36]=[CH:37][C:31]([N:25]4[CH2:26][CH2:27][O:28][CH2:29][CH2:30]4)=[CH:32][CH:33]=3)[CH:16]=2)=[C:11]([CH3:24])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

7

反応物 4

HCID 8471TriethylamineHCID 75655Benzenamine, 4-(4-morpholinyl)-HCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 598223634'-tert-Butoxycarbonylamino-2'-methyl-biphenyl-3-carboxylic acid

生成物 1

HCID 59822359[2-Methyl-3'-(4-morpholin-4-yl-phenylcarbamoyl)-biphenyl-4-yl]-carbamic acid tert-butyl ester

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 4′-tert-butoxycarbonylamino-2′-methyl-biphenyl-3-carboxylic acid (436 mg), 4-morpholin-4-yl aniline (238 mg), triethylamine (0.55 ml) and O-benzotriazol-1-yl-N,N,N′,N′-tetramethyluronium hexafluorophosphate (757 mg) in dry DMF (1 ml) was stirred at 20 C for 18 h. Water (50 ml) was then added and the resulting colourless precipitate was collected by filtration and dried (680 mg)

後処理

  1. filtrationthe resulting colourless precipitate was collected by filtration
  2. customdried (680 mg)

出典と根拠

ORDレコード
ord-b2ec8780220443e68cdffdbc65bcc0e2
出典データセット
uspto-grants-2011_08
特許番号
US08008303B2

反応ノート

読み込み中…