{4'-[4-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-ylmethyl)-phenylcarbamoyl]-6-methyl-biphenyl-3-yl}-carbamic acid tert-butyl ester → 5'-Amino-2'-methyl-biphenyl-4-carboxylic acid [4-(1,1-dioxo-1 lambda*6*-thiomorpholin-4-ylmethyl)-phenyl]-amide
反応式
C(OC(=O)[NH:7][C:8]1[CH:9]=[C:10]([C:15]2[CH:20]=[CH:19][C:18]([C:21](=[O:38])[NH:22][C:23]3[CH:28]=[CH:27][C:26]([CH2:29][N:30]4[CH2:35][CH2:34][S:33](=[O:37])(=[O:36])[CH2:32][CH2:31]4)=[CH:25][CH:24]=3)=[CH:17][CH:16]=2)[C:11]([CH3:14])=[CH:12][CH:13]=1)(C)(C)C>C(O)C.Cl>[O:37]=[S:33]1(=[O:36])[CH2:34][CH2:35][N:30]([CH2:29][C:26]2[CH:27]=[CH:28][C:23]([NH:22][C:21]([C:18]3[CH:19]=[CH:20][C:15]([C:10]4[CH:9]=[C:8]([NH2:7])[CH:13]=[CH:12][C:11]=4[CH3:14])=[CH:16][CH:17]=3)=[O:38])=[CH:24][CH:25]=2)[CH2:31][CH2:32]1参加物
4
反応物 1
生成物 1
試薬・触媒・溶媒 2
実験手順
A solution of {4′-[4-(1,1-dioxo-1lambda*6*-thiomorpholin-4-ylmethyl)-phenylcarbamoyl]-6-methyl-biphenyl-3-yl}-carbamic acid tert-butyl ester (685 mg) in ethanol (25 ml) and 6M HCl (25 ml) was stirred at 20 C for 18 h. The mixture was then basified and the ethanol evaporated. The colourless solid thus formed was collected by filtration and dried (434 mg).