Hydrochloric Acid → 5'-Amino-2'-methyl-biphenyl-4-carboxylic acid ethyl ester
反応式
[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[C:16]([NH:18]C(OC(C)(C)C)=O)[CH:15]=[CH:14][C:13]=2[CH3:26])=[CH:8][CH:7]=1)=[O:5])[CH3:2].Cl>C(O)C>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[CH:8][C:9]([C:12]2[CH:17]=[C:16]([NH2:18])[CH:15]=[CH:14][C:13]=2[CH3:26])=[CH:10][CH:11]=1)=[O:5])[CH3:2]参加物
4
実験手順
5′-tert-Butoxycarbonylamino-2′-methyl-biphenyl-4-carboxylic acid ethyl ester (6.6 g) was stirred in ethanol (120 ml) and 6M HCl (50 ml) at 20 C for 2 days. The ethanol was evaporated and the residue basified and then extracted with dichloromethane. The dried extracts were evaporated giving the title compound as a pale brown crystalline solid (4 g).
後処理
- customThe ethanol was evaporated
- extractionextracted with dichloromethane
- customThe dried extracts were evaporated
出典と根拠
- ORDレコード
- ord-d0208ae55b1741ec9f93e8e8cbfeff3b
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US08008303B2
反応ノート
読み込み中…