Hydrochloric Acid → 5'-Amino-2'-chloro-biphenyl-4-carboxylic acid ethyl ester hydrochloride

HRID 1678486ノート

反応式

HRID 1678486 の反応式
[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[C:16]([N+:18]([O-])=O)[CH:15]=[CH:14][C:13]=2[Cl:21])=[CH:8][CH:7]=1)=[O:5])[CH3:2].Cl>C(O)C>[ClH:21].[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[C:16]([NH2:18])[CH:15]=[CH:14][C:13]=2[Cl:21])=[CH:8][CH:7]=1)=[O:5])[CH3:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 598223932'-Chloro-5'-nitro-biphenyl-4-carboxylic acid ethyl ester

生成物 1

HCID 673717565'-Amino-2'-chloro-biphenyl-4-carboxylic acid ethyl ester hydrochloride収率 192.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2′-Chloro-5′-nitro-biphenyl-4-carboxylic acid ethyl ester (1.04 g) in ethanol 30 ml) and 2M HCl (5.0 ml) was hydrogenated at RTP for 3 h. The mixture was then filtered through celite and the solvent evaporated to give the title compound as a dark red solid (1.02 g) which was used in the next stage without further purification.

後処理

  1. filtrationThe mixture was then filtered through celite
  2. customthe solvent evaporated

出典と根拠

ORDレコード
ord-bc3e3e401b7e46ad99bced5cb28db57e
出典データセット
uspto-grants-2011_08
特許番号
US08008303B2

反応ノート

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