Acetic Anhydride → N-[4-(9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl)benzyl]acetamide

HRID 1678786ノート

反応式

HRID 1678786 の反応式
[C:1]1([C:7]2[C:8]([C:20]3[CH:25]=[CH:24][C:23]([CH2:26][NH2:27])=[CH:22][CH:21]=3)=[N:9][C:10]3[CH:11]=[CH:12][N:13]4[CH:19]=[N:18][N:17]=[C:14]4[C:15]=3[CH:16]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.[C:35](OC(=O)C)(=[O:37])[CH3:36]>C(O)C>[C:1]1([C:7]2[C:8]([C:20]3[CH:25]=[CH:24][C:23]([CH2:26][NH:27][C:35](=[O:37])[CH3:36])=[CH:22][CH:21]=3)=[N:9][C:10]3[CH:11]=[CH:12][N:13]4[CH:19]=[N:18][N:17]=[C:14]4[C:15]=3[CH:16]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 159792721-[4-(9-Phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl)phenyl]methanamine

生成物 1

HCID 15979533N-[4-(9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl)benzyl]acetamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 4-3 (0.02 g, 0.06 mMol) and triethylamine (0.02 mL, 0.2 mMol) in absolute ethanol (0.5 mL) was added acetic anhydride (0.02 mL, 0.2 mMol). The reaction was complete after 10 minutes and was purified directly on a C18 reverse phase HPLC to give 18-1 as a solid. LC/MS (M+1) calculated: 394.5; observed: 394.2

後処理

  1. customwas purified directly on a C18 reverse phase HPLC

出典と根拠

ORDレコード
ord-14a767a11b554f0f9014b42d5b0d556b
出典データセット
uspto-grants-2011_08
特許番号
US08008317B2

反応ノート

読み込み中…