Triethylamine → 1-[(1-Phenylethyl)sulfanyl]pyrrolidine-2,5-dione

HRID 1679285

反応式

HRID 1679285 の反応式
Cl[N:2]1[C:6](=[O:7])[CH2:5][CH2:4][C:3]1=[O:8].[C:9]1([CH:15]([SH:17])[CH3:16])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C(N(CC)CC)C>C1C=CC=CC=1>[CH3:16][CH:15]([S:17][N:2]1[C:6](=[O:7])[CH2:5][CH2:4][C:3]1=[O:8])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31398ChlorosuccinimideHCID 1418501-Phenylethanethiol

生成物 1

HCID 205546171-[(1-Phenylethyl)sulfanyl]pyrrolidine-2,5-dione収率 36.8%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒4 回

実験手順

To a suitable reactor equipped with temperature controlling means and stirring means, there are charged, while maintaining the temperature at about room temperature, N-chlorosuccinimide (about 0.30 mole) in 400 ml of benzene and 1-phenylethanethiol (about 0.30 mole) in 50 ml of benzene. After stirring the reaction mixture 10 minutes, triethylamine (0.32 mole) in 50 ml of benzene is added dropwise. The benzene mixture is stirred one hour and then filtered. The filtrate is washed three times with 250 ml portions of water and then subjected to vacuum with heating to strip off volatile components. A crystalline residue is recrystallized from ethanol to give 26 grams of N-(α-methylbenzylthio)succinimide, m.p. 121-125°C.

後処理

  1. customTo a suitable reactor equipped with temperature
  2. additionare charged
  3. temperaturewhile maintaining the temperature at about room temperature
  4. additionis added dropwise
  5. filtrationfiltered
  6. washThe filtrate is washed three times with 250 ml portions of water
  7. temperaturewith heating
  8. customA crystalline residue is recrystallized from ethanol

出典と根拠

ORDレコード
ord-a910ef935e39498f9cd87e7681119e55
出典データセット
uspto-grants-1978_03
特許番号
US04080342

関連ノート

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