1-(2-Methoxyphenyl)piperazine → HCID 70619452、化合物

HRID 1679550ノート

反応式

HRID 1679550 の反応式
[O:1]1[CH:11]2[CH:2]1[CH2:3][C:4]1[C:5]([O:14][CH3:15])=[CH:6][CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[CH2:10]2.[CH3:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1.C(O)(C)C>C1(C)C(C)=CC=CC=1>[CH3:15][O:14][C:5]1[CH:6]=[CH:7][C:8]([O:12][CH3:13])=[C:9]2[C:4]=1[CH2:3][C@@H:2]([N:27]1[CH2:26][CH2:25][N:24]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[O:17][CH3:16])[CH2:29][CH2:28]1)[C@H:11]([OH:1])[CH2:10]2

参加物

5

反応物 3

HCID 13461-(2-Methoxyphenyl)piperazineHCID 3776IsopropanolHCID 123670031a,2,7,7a-Tetrahydro-3,6-dimethoxynaphth[2,3-b]oxirene

生成物 1

HCID 70619452HCID 70619452、化合物収率 50.4%

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

A solution of 4.12 g of 6,7-epoxy-5,6,7,8-tetrahydro1,4-dimethoxynaphthalene, 4.81 g of 1-(o-methoxyphenyl)piperazine, and 1.53 ml of isopropyl alcohol in 20 ml of xylene is refluxed under nitrogen for 19 hours. The xylene is removed in vacuo and the residue triturated with ether to give 4.01 g of crude material. Two recrystallizations of this material from ethyl acetate yield 2.5 g of the title compound, melting point 182°-183° C.

後処理

  1. customThe xylene is removed in vacuo
  2. customthe residue triturated with ether

出典と根拠

ORDレコード
ord-f038e57e03be4992b52f53d6932ef122
出典データセット
uspto-grants-1978_03
特許番号
US04081444

反応ノート

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