Z-Thr(tbu)-ome → (2S,3R)-Methyl 2-amino-3-(tert-butoxy)butanoate

HRID 1679829ノート

反応式

HRID 1679829 の反応式
[CH3:1][C@@H:2]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[C@H:3]([NH:8]C(OCC1C=CC=CC=1)=O)[C:4]([O:6][CH3:7])=[O:5]>C(O)(=O)C.[C].[Pd]>[NH2:8][C@H:3]([C:4]([O:6][CH3:7])=[O:5])[C@@H:2]([CH3:1])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21]

参加物

4

反応物 1

HCID 59113197Z-Thr(tbu)-ome

生成物 1

HCID 7018834(2S,3R)-Methyl 2-amino-3-(tert-butoxy)butanoate収率 96.4%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 176Acetic Acid溶媒

実験手順

12.92 Grams (40 mmols) of Z-Thr-(tBu)-OMe in 200 ml of glacial acetic acid and 3 g of palladium carbon (10% Pd) are hydrogenated at room temperature. The absorption of hydrogen ceases after one hour. The catalyst is filtered off and the filtrate evaporated at 35° C. in a water-jet vacuum. The residue is dried in a high vacuum at 35° C. and yields 7.3 g of an oil which is unitary according to its thin-layer chromatogram and can be further used as it is.

後処理

  1. customare hydrogenated at room temperature
  2. customThe absorption of hydrogen ceases after one hour
  3. filtrationThe catalyst is filtered off
  4. customthe filtrate evaporated at 35° C. in a water-jet vacuum
  5. customThe residue is dried in a high vacuum at 35° C.

出典と根拠

ORDレコード
ord-7223f394e67d4e9f831bd7028814d954
出典データセット
uspto-grants-1981_06
特許番号
US04271068

反応ノート

読み込み中…