関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Chloro-4-(trifluoromethyl)benzene | HCID 7394 | — |
| 反応物 | Methyl 2-amino-2-methylpropanoate | HCID 4186341 | — |
| 試薬 | Sodium t-butoxide | HCID 23676156 | — |
| 触媒 | Palladium (II) acetate | HCID 4144353 | — |
| 触媒 | Bis(adamantan-1-yl)(butyl)phosphane | HCID 11371790 | — |
| 溶媒 | (Trifluoromethyl)benzene | HCID 7368 | — |
| 生成物 | Methyl 2-methyl-2-[4-(trifluoromethyl)anilino]propanoate | HCID 117559794 | 0% |
反応手順
1-chloro-4-(trifluoromethyl)benzene (0.068 mL, 0.51 mmol), methyl 2-amino-2-methylpropanoate (0.05 g, 0.43 mmol),BUTYLDI-1-ADAMANTYLPHOSPHINE (0.015 g, 0.04 mmol), sodium 2-methylpropan-2-olate (0.082 g, 0.85 mmol) and diacetoxypalladium (4.79 mg, 0.02 mmol) was added to a microwave vial. (TRIFLUOROMETHYL)-BENZENE (0.5 mL) was used as solvent, before use the solvent was bubbled with nitrogen (1-1.2 mL/mmol amine). The mixture was bubbled with nitrogen before the vial was sealed. The mixture was heated in microwave at 180° for 60min.. The mixture was heated in microwave at 180° for 60min. No conversion of startingmaterial was observed.
情報源と証拠
| 出典データセット | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-d712f5c0551541748b4f06a98eb63af5 |
|---|
| 出典メモ | 750 AstraZeneca ELN dataset |
|---|
