反応式
COC(=O)C(C)(C)N.FC(F)(F)c1ccc(Cl)cc1>CC(=O)O.CC(=O)O.CC(C)(C)[O-].CCCCP(C12CC3CC(CC(C3)C1)C2)C12CC3CC(CC(C3)C1)C2.FC(F)(F)c1ccccc1.[Na+].[Pd]>COC(=O)C(C)(C)Nc1ccc(C(F)(F)F)cc1参加物
7
反応物 2
生成物 1
試薬・触媒・溶媒 4
反応条件
- 温度
- 180 °C
実験手順
1-chloro-4-(trifluoromethyl)benzene (0.068 mL, 0.51 mmol), methyl 2-amino-2-methylpropanoate (0.05 g, 0.43 mmol),BUTYLDI-1-ADAMANTYLPHOSPHINE (0.015 g, 0.04 mmol), sodium 2-methylpropan-2-olate (0.082 g, 0.85 mmol) and diacetoxypalladium (4.79 mg, 0.02 mmol) was added to a microwave vial. (TRIFLUOROMETHYL)-BENZENE (0.5 mL) was used as solvent, before use the solvent was bubbled with nitrogen (1-1.2 mL/mmol amine). The mixture was bubbled with nitrogen before the vial was sealed. The mixture was heated in microwave at 180° for 60min.. The mixture was heated in microwave at 180° for 60min. No conversion of startingmaterial was observed.
出典と根拠
- ORDレコード
- ord-d712f5c0551541748b4f06a98eb63af5
- 出典データセット
- 750 AstraZeneca ELN dataset
- 元リンク
- 出典を表示
関連ノート
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