Z-Gln-ONp → H-Gln-Thr-Pro-OtBu

HRID 1680052ノート

反応式

HRID 1680052 の反応式
[NH2:1][C@H:2]([C:6]([N:8]1[CH2:19][CH2:18][CH2:17][C@H:9]1[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])=[O:7])[C@@H:3]([CH3:5])[OH:4].C1C=CC(COC([NH:30][C@H:31]([C:37](OC2C=CC([N+]([O-])=O)=CC=2)=[O:38])[CH2:32][CH2:33][C:34]([NH2:36])=[O:35])=O)=CC=1>CN(C=O)C>[NH2:30][C@H:31]([C:37]([NH:1][C@H:2]([C:6]([N:8]1[CH2:19][CH2:18][CH2:17][C@H:9]1[C:10]([O:12][C:13]([CH3:15])([CH3:14])[CH3:16])=[O:11])=[O:7])[C@@H:3]([CH3:5])[OH:4])=[O:38])[CH2:32][CH2:33][C:34](=[O:35])[NH2:36]

参加物

4

反応物 2

HCID 111333Z-Gln-ONpHCID 131712118H-Thr-Pro-OtBu

生成物 1

HCID 131712117H-Gln-Thr-Pro-OtBu

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

1.36 g H-Thr-Pro-OtBu is dissolved in 10 ml DMF, after which 1.93 g Z-Gln-ONp is added and the reaction mixture is stirred for about 20 hours at room temperature. After evaporation of the mixture to dryness, the residue is dissolved in EtOAc and washed consecutively with 5% KHSO4 solution, 5% NaHCO3 solution and a saturated NaCl solution. The solution is then dried over Na2SO4 and filtered, and the filtrate is evaporated to dryness.

後処理

  1. customAfter evaporation of the mixture to dryness
  2. dissolutionthe residue is dissolved in EtOAc
  3. washwashed consecutively with 5% KHSO4 solution, 5% NaHCO3 solution
  4. dry with materialThe solution is then dried over Na2SO4
  5. filtrationfiltered
  6. customthe filtrate is evaporated to dryness

出典と根拠

ORDレコード
ord-b22a67e408404ba19122d28e54dd56bc
出典データセット
uspto-grants-1981_06
特許番号
US04271152

反応ノート

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