Z-Lys(Boc)-ONp → Z-Lys(Boc)-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-OtBu

HRID 1680054ノート

反応式

HRID 1680054 の反応式
[CH3:1][C:2]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][C@H:13]([NH:26][C:27]([O:29][CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)=[O:28])[C:14]([O:16]C1C=CC([N+]([O-])=O)=CC=1)=O)=[O:7])([CH3:4])[CH3:3].[NH2:37][C@H:38]([C:41]([NH:43][C@H:44]([C:50]([NH:52][C@H:53]([C:57]([N:59]1[CH2:100][CH2:99][CH2:98][C@H:60]1[C:61]([NH:63][C@H:64]([C:69]([NH:71][C@H:72]([C:76]([NH:78][C@H:79]([C:83]([NH:85][C@H:86]([C:91]([O:93][C:94]([CH3:97])([CH3:96])[CH3:95])=[O:92])[CH2:87][CH:88]([CH3:90])[CH3:89])=[O:84])[C@@H:80]([CH3:82])[OH:81])=[O:77])[CH:73]([CH3:75])[CH3:74])=[O:70])[CH2:65][CH:66]([CH3:68])[CH3:67])=[O:62])=[O:58])[C@@H:54]([CH3:56])[OH:55])=[O:51])[CH2:45][CH2:46][C:47](=[O:49])[NH2:48])=[O:42])[CH2:39][OH:40]>CN(C=O)C>[NH:26]([C:27]([O:29][CH2:30][C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)=[O:28])[C@H:13]([C:14]([NH:37][C@H:38]([C:41]([NH:43][C@H:44]([C:50]([NH:52][C@H:53]([C:57]([N:59]1[CH2:100][CH2:99][CH2:98][C@H:60]1[C:61]([NH:63][C@H:64]([C:69]([NH:71][C@H:72]([C:76]([NH:78][C@H:79]([C:83]([NH:85][C@H:86]([C:91]([O:93][C:94]([CH3:96])([CH3:95])[CH3:97])=[O:92])[CH2:87][CH:88]([CH3:89])[CH3:90])=[O:84])[C@@H:80]([CH3:82])[OH:81])=[O:77])[CH:73]([CH3:74])[CH3:75])=[O:70])[CH2:65][CH:66]([CH3:67])[CH3:68])=[O:62])=[O:58])[C@@H:54]([CH3:56])[OH:55])=[O:51])[CH2:45][CH2:46][C:47](=[O:49])[NH2:48])=[O:42])[CH2:39][OH:40])=[O:16])[CH2:12][CH2:11][CH2:10][CH2:9][NH:8][C:6]([O:5][C:2]([CH3:1])([CH3:3])[CH3:4])=[O:7]

参加物

4

反応物 2

HCID 13503265Z-Lys(Boc)-ONpHCID 131712256H-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-OtBu

生成物 1

HCID 131712255Z-Lys(Boc)-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-OtBu

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

1.35 g Z-Lys(Boc)-ONp (2.7 mmol) and 2.42 g (2.64 mmol) H-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-OtBu (F. 1) are dissolved in 35 ml DMF. After stirring at room temperature for 18 hours the reaction mixture is evaporated to dryness.

後処理

  1. customis evaporated to dryness

出典と根拠

ORDレコード
ord-09eca54661dc45849e6068ba366ff1f2
出典データセット
uspto-grants-1981_06
特許番号
US04271152

反応ノート

読み込み中…