Dichloroacetyl chloride → HCID 13309297、化合物
反応式
[CH:1]([NH:4][CH2:5][C:6]#[CH:7])([CH3:3])[CH3:2].C(N(CC)CC)C.[Cl:15][CH:16]([Cl:20])[C:17](Cl)=[O:18]>C1(C)C=CC=CC=1>[CH:1]([N:4]([CH2:5][C:6]#[CH:7])[C:17](=[O:18])[CH:16]([Cl:20])[Cl:15])([CH3:3])[CH3:2]参加物
5
実験手順
118 g of isopropylpropargylamine and 123 g of triethylamine are dissolved in 670 ml of toluene. While cooling and at room temperature, a solution of 180 g of dichloroacetyl chloride in 450 ml of toluene is dripped into this solution. The mixture is allowed to react for 1 hour before being filtered, and the filtrate is washed with water. The residue remaining after removal of the solvent is washed with petroleum ether. There is obtained 214 g (84% of theory) of N-isopropyl-N-propargyldichloroacetamide; b.p. (0.013 mbar): 80°-82° C.; m.p.: 58°-59° C.
後処理
- customto react for 1 hour
- filtrationbefore being filtered
- washthe filtrate is washed with water
- customafter removal of the solvent
- washis washed with petroleum ether
出典と根拠
- ORDレコード
- ord-6e337ad1443b426797f781b212427801
- 出典データセット
- uspto-grants-1981_06
- 特許番号
- US04272282
反応ノート
読み込み中…