Hydrochloric Acid → HCID 23457161、化合物

HRID 1680152ノート

反応式

HRID 1680152 の反応式
[Cl:1][C:2]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:3]=1[NH:4][C:5]1[C:6]([CH2:10]O)=[CH:7][S:8][CH:9]=1.[ClH:17]>>[Cl:1][C:2]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:3]=1[NH:4][C:5]1[C:6]([CH2:10][Cl:17])=[CH:7][S:8][CH:9]=1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 234571594-(2,6-Dichloroanilino)-3-thiophenemethanol

生成物 1

HCID 23457161HCID 23457161、化合物

実験手順

27.4 g (0.1 mole) of 4-(2,6-dichloroanilino)-3-thiophenmethanol are dissolved in 800 ml of concentrated aqueous hydrochloric acid, and the solution is left to stand for eight hours, poured onto ice and extracted with toluene. The organic phase is washed with sodium bicarbonate solution, dried and concentrated. Recrystallization of the residue from petroleum ether gives 3-(2,6-dichloroanilino)-4-chloromethylthiophen (m. 89° to 92°).

後処理

  1. waitthe solution is left
  2. additionpoured onto ice
  3. extractionextracted with toluene
  4. washThe organic phase is washed with sodium bicarbonate solution
  5. customdried
  6. concentrationconcentrated
  7. customRecrystallization of the residue from petroleum ether

出典と根拠

ORDレコード
ord-16231ea2333b4d1b814177caa6dbfbce
出典データセット
uspto-grants-1981_06
特許番号
US04272507

反応ノート

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