Phosphorus pentachloride → N-(2,6-dichlorophenyl)-2,3-dihydro-2-oxothieno[3,4-b]pyrrole

HRID 1680171ノート

反応式

HRID 1680171 の反応式
[Cl:1][C:2]1[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[C:3]=1[NH:4][C:5]1[C:6]([CH2:10][C:11](O)=[O:12])=[CH:7][S:8][CH:9]=1.P(Cl)(Cl)(Cl)(Cl)Cl>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[C:3]=1[N:4]1[C:11](=[O:12])[CH2:10][C:6]2=[CH:7][S:8][CH:9]=[C:5]12

参加物

4

反応物 2

HCID 24819Phosphorus pentachlorideHCID 51717Eltenac

生成物 1

HCID 23457240N-(2,6-dichlorophenyl)-2,3-dihydro-2-oxothieno[3,4-b]pyrrole

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

1 g (0.33 mmole) of 4-(2,6-dichloroanilino)-3-thiophenacetic acid and 0.7 g (0.33 mmole) of phosphorus pentachloride are stirred in 10 ml of toluene at room temperature for half an hour. The mixture is extracted with water and sodium bicarbonate solution, clarified with bleaching earth (for example Tonsil®) and concentrated. Recrystallization of the residue from isopropanol yields N-(2,6-dichlorophenyl)-2,3-dihydro-2-oxothieno[3,4-b]pyrrole (m. 187° to 188°).

後処理

  1. extractionThe mixture is extracted with water and sodium bicarbonate solution
  2. concentrationconcentrated
  3. customRecrystallization of the residue from isopropanol

出典と根拠

ORDレコード
ord-142fa22fbd3b4f498e995f2f7de0a3d6
出典データセット
uspto-grants-1981_06
特許番号
US04272507

反応ノート

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