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1-Bromo-3-methylbutane → 15-Methylhexadecyl bromide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Bromo-3-methylbutane | HCID 7891 | — |
| 反応物 | 1,12-Dibromododecane | HCID 18766 | — |
| 反応物 | Magnesium | HCID 5462224 | — |
| 触媒 | Copper;dilithium;tetrachloride | HCID 193501 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 15-Methylhexadecyl bromide | HCID 20437385 | — |
| 生成物 | HCID 178418529 | HCID 178418529 | — |
反応手順
A solution of 3-methylbutylmagnesium bromide is prepared by treating 15 g. (0.1 mole) 3-methylbutyl bromide with 2.7 g. (1.1 eq) magnesium turnings in 50 ml. dry tetrahydrofuran. The resultant Grignard reagent is dropwise added to a cold (-10° C.) solution of 36.1 g. (1.1 eq) 1,12-dibromododecane and 0.2 g. (1 m mole) dilithiumtetrachloro cuprate in 75 ml. dry tetrahydrofuran. The solution is stirred for one hour, evaporated, and fractionally distilled in vacuo to yield 15-methylhexadecylbromide as a colorless liquid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04272546 |
| 出典データセット | uspto-grants-1981_06 |
| ORD ID | ord-e2a90b0c8706459a91b19be9454079b7 |
| 出典メモ | uspto-grants-1981_06 |