Hydrochloric Acid → methyl L-phenylalanyl-3-amino-1-adamantanecarboxylate hydrochloride

HRID 1680571

反応式

HRID 1680571 の反応式
C([NH:8][C@H:9]([C:17]([CH:19]1[C:26]2([NH2:28])[CH2:27][CH:22]3[CH2:23][CH:24]([CH2:29][C:20]1([C:30]([O:32][CH3:33])=[O:31])[CH2:21]3)[CH2:25]2)=[O:18])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(OC(C)(C)C)=O.[ClH:34]>O1CCOCC1>[ClH:34].[NH2:8][C@H:9]([C:17]([CH:19]1[C:26]2([NH2:28])[CH2:27][CH:22]3[CH2:23][CH:24]([CH2:29][C:20]1([C:30]([O:32][CH3:33])=[O:31])[CH2:21]3)[CH2:25]2)=[O:18])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 70566312methyl Boc-phenylalanyl-3-amino-1-adamantanecarboxylate

生成物 1

HCID 70565564methyl L-phenylalanyl-3-amino-1-adamantanecarboxylate hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

5.48 g of methyl Boc-phenylalanyl-3-amino-1-adamantanecarboxylate is dissolved in 15 ml of dioxane and 20 ml of a 5.9 M solution of hydrogen chloride in dioxane is added. After standing for 10 minutes at room temperature the solvent is removed under reduced pressure and the residue is stirred with diethyl ether. The crystalline product is collected by filtration, washed with diethyl ether and dried in a vacuum oven for 16 hours at 50° C. and 0.1 mm pressure to give methyl L-phenylalanyl-3-amino-1-adamantanecarboxylate hydrochloride which is represented by the following formula ##STR24##

後処理

  1. customthe solvent is removed under reduced pressure
  2. filtrationThe crystalline product is collected by filtration
  3. washwashed with diethyl ether
  4. customdried in a vacuum oven for 16 hours at 50° C.

出典と根拠

ORDレコード
ord-47a06edf424944b2b6762ac2279364ed
出典データセット
uspto-grants-1981_06
特許番号
US04273704

関連ノート

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