Imidazole → 2-(1H-Imidazol-1-yl)-1-(4-(2-phenylethyl)phenyl)ethanone

HRID 1680649ノート

反応式

HRID 1680649 の反応式
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.Cl[CH2:7][C:8]([C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:12][CH:11]=1)=[O:9].O>CN(C)C=O>[N:1]1([CH2:7][C:8]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:12][CH:11]=2)=[O:9])[CH:5]=[CH:4][N:3]=[CH:2]1

参加物

5

反応物 3

HCID 795ImidazoleHCID 962WaterHCID 30087272-Chloro-1-[4-(2-phenylethyl)phenyl]ethan-1-one

生成物 1

HCID 527582-(1H-Imidazol-1-yl)-1-(4-(2-phenylethyl)phenyl)ethanone収率 77.4%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution containing 3.4 g of imidazole in 5 ml of dimethylformamide, stirred at 0/+5° C., 2.58 g of 4-chloroacetyl-bibenzyl were slowly added. The reaction mixture was stirred for few minutes, then allowed to stand and then poured into water. The product thus formed was filtered off, purified by silica gel column chromatography (eluant: benzene/acetone) and then crystallized from ethyl acetate to give 2.24 g of the title compound melting at 134°-6° C. Yield 77%.

後処理

  1. additionwere slowly added
  2. customThe product thus formed
  3. filtrationwas filtered off
  4. custompurified by silica gel column chromatography (eluant: benzene/acetone)
  5. customcrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-e6e495a422b34154a5a1fc4db748d16f
出典データセット
uspto-grants-1981_06
特許番号
US04275071

反応ノート

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