Imidazole → Acetophenone, 2-(1-imidazolyl)-2',3',5',6'-tetramethyl-

HRID 1680650ノート

反応式

HRID 1680650 の反応式
Br[CH2:2][C:3]([C:5]1[C:11]([CH3:12])=[C:10]([CH3:13])[CH:9]=[C:7]([CH3:8])[C:6]=1[CH3:14])=[O:4].CN(C)C=O.[NH:20]1[CH:24]=[CH:23][N:22]=[CH:21]1>O>[N:20]1([CH2:2][C:3]([C:5]2[C:11]([CH3:12])=[C:10]([CH3:13])[CH:9]=[C:7]([CH3:8])[C:6]=2[CH3:14])=[O:4])[CH:24]=[CH:23][N:22]=[CH:21]1

参加物

5

反応物 3

HCID 795ImidazoleHCID 6228DimethylformamideHCID 2648242-bromo-1-(2,3,5,6-tetramethylphenyl)ethanone

生成物 1

HCID 52759Acetophenone, 2-(1-imidazolyl)-2',3',5',6'-tetramethyl-収率 62%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

A mixture containing 2.55 g of 3-bromoacetyl-durene, prepared as described in Example 4, 3 ml of dimethylformamide and 3.40 g of imidazole, was stirred for 8 hours at 80° C. At the end of the reaction, the mixture was cooled to room temperature and 25 ml of water were added. The precipitate thus obtained was filtered off, dried and crystallized from benzene to give 1.5 g of the title compound. M.P. 176°-8° C., yield 62%.

後処理

  1. customprepared
  2. customAt the end of the reaction
  3. temperaturethe mixture was cooled to room temperature
  4. customThe precipitate thus obtained
  5. filtrationwas filtered off
  6. customdried
  7. customcrystallized from benzene

出典と根拠

ORDレコード
ord-432d2bfa73a04984a77de39e461e182b
出典データセット
uspto-grants-1981_06
特許番号
US04275071

反応ノート

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