Potassium Carbonate → HCID 54012844、化合物

HRID 1680855ノート

反応式

HRID 1680855 の反応式
[CH:1]1([C:4]([OH:6])=[O:5])[CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].[CH3:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][CH:23]=1)[CH:20]=[C:19]([CH2:24]Br)[CH:18]=[CH:17]2>CC(C)=O>[CH3:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][CH:23]=1)[CH:20]=[C:19]([CH2:24][O:5][C:4]([CH:1]1[CH2:3][CH2:2]1)=[O:6])[CH:18]=[CH:17]2

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 15655Cyclopropanecarboxylic acidHCID 123373022-(Bromomethyl)-6-methylnaphthalene

生成物 1

HCID 54012844HCID 54012844、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒2 回

反応条件

温度
50 °C

実験手順

1.89 g of cyclopropane carboxylic acid are dissolved in 50 ml of acetone, treated with 5.5 g of potassium carbonate and heated to 50° C. A solution of 4.7 g of 6-methyl-2-(bromomethyl)naphthalene in 20 ml of acetone is then added dropwise. The mixture is left to react at 65° C. for 15 hours. The mixture is cooled and filtered. The residue is then rinsed with acetone and the filtrate is evaporated. The residue is purified chromatography on silica gel with hexane/ethyl acetate (9:1) to yield pure cyclopropane carboxylic acid (6-methyl-2-naphthyl)methyl ester of melting point 75°-78° C. (from petane/ether).

後処理

  1. waitThe mixture is left
  2. customto react at 65° C. for 15 hours
  3. temperatureThe mixture is cooled
  4. filtrationfiltered
  5. washThe residue is then rinsed with acetone
  6. customthe filtrate is evaporated
  7. customThe residue is purified chromatography on silica gel with hexane/ethyl acetate (9:1)

出典と根拠

ORDレコード
ord-5635dae7c6424c1b9c7cfee98d8ce001
出典データセット
uspto-grants-1981_06
特許番号
US04276305

反応ノート

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