Ammonia → 2-(2,3-Dichlorophenoxy)acetamidine hydrochloride

HRID 1681020ノート

反応式

HRID 1681020 の反応式
Cl.[Cl:2][C:3]1[C:15]([Cl:16])=[CH:14][CH:13]=[CH:12][C:4]=1[O:5][CH2:6][C:7](=[NH:11])OCC.[NH3:17]>C(O)C>[ClH:2].[Cl:2][C:3]1[C:15]([Cl:16])=[CH:14][CH:13]=[CH:12][C:4]=1[O:5][CH2:6][C:7]([NH2:11])=[NH:17]

参加物

4

反応物 2

HCID 222AmmoniaHCID 19736212Ethyl 2-(2,3-dichlorophenoxy)acetimidate hydrochloride

生成物 1

HCID 197362082-(2,3-Dichlorophenoxy)acetamidine hydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

11.8 g (0.041 mole) of ethyl 2-(2,3-dichlorophenoxy)acetimidate hydrochloride are added rapidly to a solution, cooled to 10° C., of 3.5 g (0.21 mole) of ammonia in 100 ml of absolute ethanol. The reaction mixture is left for 3 days at room temperature. After removal of a few suspended particles by filtration, the reaction mixture is concentrated to dryness under reduced pressure. The solid residue obtained is purified by washing with ether and recrystallization from isopropanol. Yld: 8.0 g (75%), m.p. 204.5°-206.5° C.

後処理

  1. customAfter removal of
  2. filtrationby filtration
  3. concentrationthe reaction mixture is concentrated to dryness under reduced pressure
  4. customThe solid residue obtained
  5. customis purified
  6. washby washing with ether and recrystallization from isopropanol

出典と根拠

ORDレコード
ord-7ed34ba279f241fca5e778a08113d443
出典データセット
uspto-grants-1992_12
特許番号
US05167949

反応ノート

読み込み中…