3-Amino-6-methylpyrazine-2-carbonitrile → 4-Amino-2-ethoxymethyl-6-methylpteridine
反応式
[NH2:1][C:2]1[C:3]([C:9]#[N:10])=[N:4][C:5]([CH3:8])=[CH:6][N:7]=1.[CH2:11]([O:13][CH2:14][C:15](N)=[NH:16])[CH3:12]>>[NH2:10][C:9]1[C:3]2[C:2](=[N:7][CH:6]=[C:5]([CH3:8])[N:4]=2)[N:1]=[C:15]([CH2:14][O:13][CH2:11][CH3:12])[N:16]=1参加物
3
実験手順
A suspension of 15.1 g (0.113 mole) of 3-amino-6-methyl-2-pyrazinecarbonitrile [prepared according to E. C. Taylor et al., J. Am. Chem. Soc. 1973, 95, 6413] in the above ethanolic solution of 2-ethoxyacetamidine is refluxed for 2 hours. After cooling, the solution obtained is concentrated to dryness under reduced pressure. The residue is purified by washing with acetone and recrystallization from a mixture of acetone and isopropyl ether. Yld: 8.4 g (34%), m.p. 166°-168° C.
後処理
- temperatureis refluxed for 2 hours
- temperatureAfter cooling
- customthe solution obtained
- concentrationis concentrated to dryness under reduced pressure
- customThe residue is purified
- washby washing with acetone and recrystallization from a mixture of acetone and isopropyl ether
出典と根拠
- ORDレコード
- ord-ee4eebec7605483e952468842d8893b4
- 出典データセット
- uspto-grants-1992_12
- 特許番号
- US05167949
反応ノート
読み込み中…