Sulfuric Acid → Pyrazolo[1,5-a]pyrimidine-3-carboxamide
反応式
[N:1]1[N:5]2[CH:6]=[CH:7][CH:8]=[N:9][C:4]2=[C:3]([C:10]#[N:11])[CH:2]=1.S(=O)(=O)(O)[OH:13]>>[N:1]1[N:5]2[CH:6]=[CH:7][CH:8]=[N:9][C:4]2=[C:3]([C:10]([NH2:11])=[O:13])[CH:2]=1参加物
3
実験手順
As shown hereinabove a pyrazolo(1,5-a)-pyrimidine-3-carbonitrile (4) (prepared in the manner described in U.S. Pat. Nos. 4,281,000; 4,236,005 and 4,178,499) is stirred with concentrated sulfuric acid at room temperature for from 2-20 hours. The mixture is carefully poured onto ice and the precipitate is collected, neutralized with sodium hydroxide, ammonium hydroxide or saturated sodium bicarbonate and the like and washed with water to obtain the corresponding pyrazolo(1,5-a)pyrimidine-3-carboxamide compound (3).
後処理
- customprepared in the manner
- additionThe mixture is carefully poured onto ice
- customthe precipitate is collected
- washthe like and washed with water
出典と根拠
- ORDレコード
- ord-3fa3787ddf314a6a8a2ac3650bd241ab
- 出典データセット
- uspto-grants-1992_12
- 特許番号
- US05169850
反応ノート
読み込み中…