Hydrochloric Acid → 1-(4-Bromo-2,5-difluorophenyl)ethan-1-one

HRID 1681184ノート

反応式

HRID 1681184 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[Br:9].[Cl-].[Al+3].[Cl-].[Cl-].[C:14](Cl)(=[O:16])[CH3:15].Cl>>[CH3:15][C:14]([C:6]1[C:5]([F:8])=[CH:4][C:3]([Br:9])=[C:2]([F:1])[CH:7]=1)=[O:16]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 678622-Bromo-1,4-difluorobenzeneHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 99916531-(4-Bromo-2,5-difluorophenyl)ethan-1-one収率 76%

反応条件

温度
95 °C

実験手順

To a stirred mixture of 20 g 2,5-difluorobromobenzene and 35,2 g aluminum chloride under nitrogen at 60° C. was added dropwise 11.2 ml acetyl chloride. The reaction mixture was stirred at 95° C. for 90 min. and then poured over 250 g ice followed by 17 ml concentrated hydrochloric acid. The aqueous mixture was extracted with ether, and the extracts washed with sodium chloride solution and concentrated. The residue (23.6 g) was distilled in vacuo to give 18.4 g (76%) 4-bromo-2,5-difluoroacetophenone, b.p. 65° C. (0.1 mm).

後処理

  1. extractionThe aqueous mixture was extracted with ether
  2. washthe extracts washed with sodium chloride solution
  3. concentrationconcentrated
  4. distillationThe residue (23.6 g) was distilled in vacuo

出典と根拠

ORDレコード
ord-3de26d3486fc44f4a2f4ede52cebe853
出典データセット
uspto-grants-1992_12
特許番号
US05169853

反応ノート

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