Hexamethylphosphoramide → 1-Cyclopropyl-7-(2,6-dimethylpyridinyl)-5,6,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

反応式

Br[C:2]1[C:11]([F:12])=[C:10]2[C:5]([C:6](=[O:21])[C:7]([C:16]([O:18]CC)=[O:17])=[CH:8][N:9]2[CH:13]2[CH2:15][CH2:14]2)=[C:4]([F:22])[C:3]=1[F:23].[CH3:24][C:25]1[CH:30]=[C:29]([Sn](C)(C)C)[CH:28]=[C:27]([CH3:35])[N:26]=1.CN(C)P(N(C)C)(N(C)C)=O>Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.O1CCOCC1>[CH:13]1([N:9]2[C:10]3[C:5](=[C:4]([F:22])[C:3]([F:23])=[C:2]([C:30]4[C:25]([CH3:24])=[N:26][C:27]([CH3:35])=[CH:28][CH:29]=4)[C:11]=3[F:12])[C:6](=[O:21])[C:7]([C:16]([OH:18])=[O:17])=[CH:8]2)[CH2:15][CH2:14]1