Ammonium Hydroxide → HCID 178516142、化合物
反応式
[F:1][C:2]([F:16])([F:15])[C:3](=O)[CH2:4][C:5](=[O:13])[CH2:6][C:7]([C:9]([F:12])([F:11])[F:10])=O.[OH-].[NH4+:18]>>[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([OH:13])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[N:18]=1参加物
3
反応条件
- 温度
- 130 °C
実験手順
A mixture of 30 g 1,5-di(trifluoromethyl)-1,3,5-trioxopentane and 125 ml 28% aqueous ammonium hydroxide was heated in an autoclave at 130° C. for 5 hours. The reaction mixture was concentrated in vacuo, dissolved in 350 ml ethanol and treated with 11 ml 6N hydrochloric acid. The resulting mixture was concentrated in vacuo, 100 ml water added to the residue and filtered to give 8.0 g 2,6-di(trifluoromethyl)-4-hydroxypyridine, m.p. 123°-130° C.
後処理
- concentrationThe reaction mixture was concentrated in vacuo
- dissolutiondissolved in 350 ml ethanol
- additiontreated with 11 ml 6N hydrochloric acid
- concentrationThe resulting mixture was concentrated in vacuo, 100 ml water
- additionadded to the residue
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-dec5f2061bb746b79ca7ef18cd3eadc1
- 出典データセット
- uspto-grants-1992_12
- 特許番号
- US05169853
反応ノート
読み込み中…