Phosphorus tribromide → 4-Bromo-2,6-bis(trifluoromethyl)pyridine

HRID 1681200ノート

反応式

HRID 1681200 の反応式
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:8]=[C:7](O)[CH:6]=[C:5]([C:10]([F:13])([F:12])[F:11])[N:4]=1.P(Br)(Br)[Br:17]>C(Cl)Cl>[Br:17][C:7]1[CH:8]=[C:3]([C:2]([F:15])([F:14])[F:1])[N:4]=[C:5]([C:10]([F:13])([F:12])[F:11])[CH:6]=1

参加物

4

反応物 2

HCID 24614Phosphorus tribromideHCID 178516142HCID 178516142、化合物

生成物 1

HCID 150303204-Bromo-2,6-bis(trifluoromethyl)pyridine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A mixture of 6 g 2,6-di(trifluoromethyl)-4-hydroxypyridine and 4.9 ml phosphorus tribromide was heated 15 min. at 140°-150° C. and 90 min. at 160°-170° C. The reaction mixture was cooled, 150 ml methylene dichloride added, and poured into ice-water. From the methylene dichloride layer there was isolated 3.5 g 4-bromo-2,6-di(trifluoromethyl)pyridine, colorless solid, m.p. 92°-95° C.

後処理

  1. temperaturewas heated 15 min. at 140°-150° C. and 90 min. at 160°-170° C
  2. temperatureThe reaction mixture was cooled

出典と根拠

ORDレコード
ord-405f2910cbf24edeb607b63099879c79
出典データセット
uspto-grants-1992_12
特許番号
US05169853

反応ノート

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