Toluene → 5-Chloro-2-nitrobenzaldehyde diethyacetal
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:10]([O-:12])=[O:11])=[C:6]([CH:9]=1)[CH:7]=[O:8].[C:13]1([CH3:19])C=CC=CC=1.[OH2:20].[C:21]1(C)C=CC(S(O)(=O)=O)=C[CH:22]=1>O>[CH2:21]([O:8][CH:7]([O:20][CH2:13][CH3:19])[C:6]1[CH:9]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=1[N+:10]([O-:12])=[O:11])[CH3:22]参加物
5
実験手順
A mixture of 5-chloro-2-nitrobenzaldehyde (5.0 g), toluene (50 ml), p-toluenesulfonic acid monohydrate (25 mg) was heated under stirring for 2 hours by dehydrating water which was formed in the course of reaction. The solvent was distilled under reduced pressure and the residue was column chromatographed (hexane/ethyl acetate: 8/1) to give 6.5 g of the pure title compound (93%).
後処理
- temperaturewas heated
- customwas formed in the course of reaction
- distillationThe solvent was distilled under reduced pressure
- customchromatographed (hexane/ethyl acetate: 8/1)
出典と根拠
- ORDレコード
- ord-762d8d9f3b824d3d867bce3db879c174
- 出典データセット
- uspto-grants-1992_12
- 特許番号
- US05171851
反応ノート
読み込み中…