2-Methylimidazole → HCID 10977186、化合物

反応式

C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([CH:11]2[CH2:13][CH2:12]2)=O)=[CH:5][CH:4]=1.[CH3:14][C:15]1[NH:16][CH:17]=[CH:18][N:19]=1>>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[C:17]3[N:16]([C:15]([CH3:14])=[N:19][CH:18]=3)[CH2:12][CH2:13][CH:11]=2)=[CH:7][CH:8]=1

参加物

反応物 2

HCID 127492-Methylimidazole

HCID 81580p-Anisoylcyclopropane

生成物 1

HCID 10977186HCID 10977186、化合物

反応条件

温度: 225 °C

実験手順

25 g (0.14 mol) of cyclopropyl 4-methoxyphenyl ketone is combined with 50 g (0.61 mol) of 2-methylimidazole and heated to 225° C. under nitrogen for 16 hr. The reaction is extracted with sodium hydroxide solution and the extract neutralized with ammonium chloride. Recrystallization from methylene chloride/methanol (1:1) provides the title compound.

後処理

extractionThe reaction is extracted with sodium hydroxide solution
customRecrystallization from methylene chloride/methanol (1:1)

出典と根拠

ORDレコード: ord-59f2f41d52514aa6b8cdfb7ae1f00826
出典データセット: uspto-grants-1992_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05171858

反応ノート

読み込み中…

参加物