Ethyl 3-ethylaminomethyl-3-hydroxypyrrolidine-1-carboxylate → 3-Ethylaminomethyl-3-hydroxypyrrolidine
反応式
[CH2:1]([NH:3][CH2:4][C:5]1([OH:15])[CH2:9][CH2:8][N:7](C(OCC)=O)[CH2:6]1)[CH3:2]>O>[CH2:1]([NH:3][CH2:4][C:5]1([OH:15])[CH2:9][CH2:8][NH:7][CH2:6]1)[CH3:2]参加物
3
実験手順
7.7 g (35.6 mmol) of ethyl 3-ethylaminomethyl-3hydroxypyrrolidine-1-carboxylate are heated under reflux overnight with 22 g of Ba(OH)2. 8H2O in 220 ml of water. The mixture is filtered off with suction from BaCO3 and concentrated. The residue is boiled five times using 100 m of dioxane each time, and the dioxane solution is concentrated and distilled.
後処理
- filtrationThe mixture is filtered off with suction from BaCO3
- concentrationconcentrated
- concentrationthe dioxane solution is concentrated
- distillationdistilled
出典と根拠
- ORDレコード
- ord-78aa25cbb4834f62833ab37ece93f316
- 出典データセット
- uspto-grants-1992_12
- 特許番号
- US05173484
反応ノート
読み込み中…